Synthesis and antiproliferative activity of flavonoid triazolyl glycosides.

Sixteen flavonoid triazolyl glycosides <bold>4–19</bold> were synthesized in good yields <italic>via</italic> Cu(I)-catalyzed azide-alkyne cycloadditions of terminal alkynes of flavonoids <bold>1–3</bold> with acetylated sugar azides followed by deacetylation with sodium methoxide in anhydrous methanol. The antiproliferative activity of the synthesized compounds against three human cancer cell lines (Hela, HCC1954 and SK-OV-3) <italic>in vitro</italic> was evaluated. Flavonoids <bold>1</bold>, <bold>2</bold> and flavonoid triazolyl glycosides <bold>7</bold>, <bold>12</bold>, <bold>17</bold> exhibit potent antiproliferative activity against these cancer cell lines. [ABSTRACT FROM AUTHOR]