Back to Search
Start Over
Asymmetric Catalytic [4 + 2] Cycloaddition via Cu–Allenylidene Intermediate: Stereoselective Synthesis of Tetrahydroquinolines Fused with a γ-Lactone Moiety.
- Source :
-
Organic Letters . 4/6/2018, Vol. 20 Issue 7, p1760-1763. 4p. - Publication Year :
- 2018
-
Abstract
- A decarboxylative formal [4 + 2] cycloaddition reaction between ethynyl benzoxazinanones and 5-substituted 2-silyloxyfurans catalyzed by chiral Cu–Pybox complex is described. This method allows the formation of intriguing tetrahydroquinolines fused with a butyrolactone moiety featuring three contiguous chiral centers in high yields with excellent diastereo- and enantioselectivities in most cases. The utility of this method was exemplified by the removal of the N-protecting groups and derivatization on the terminal alkyne functionality of the cyclization products. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 20
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 129168731
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b00253