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Cascade Radical 1,6-Addition/Cyclization of para-Quinone Methides: Leading to Spiro[4.5]deca-6,9-dien-8-ones.
- Source :
-
Organic Letters . 4/6/2018, Vol. 20 Issue 7, p1974-1977. 4p. - Publication Year :
- 2018
-
Abstract
- A cascade three-component iodoazidation of para-quinone methides to construct spiro[4.5]deca-6,9-dien-8-ones under mild conditions has been developed. The chemoselective 1,6-addition of azide radical triggered a regioselective 5-exo-dig cyclization/radical coupling sequence, enabling C–N, C–C, and C–I bond formations in a one-pot procedure with high efficiency. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 20
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 129169672
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b00518