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Engineered agrin attenuates the severity of experimental autoimmune myasthenia gravis.
- Source :
-
Muscle & Nerve . May2018, Vol. 57 Issue 5, p814-820. 7p. - Publication Year :
- 2018
-
Abstract
- <bold>Introduction: </bold>Agrin is essential for the formation and maintenance of neuromuscular junctions (NMJs). NT-1654 is a C-terminal fragment of mouse neural agrin. In this study, we determined the effects of NT-1654 on the severity of experimental autoimmune myasthenia gravis (EAMG).<bold>Methods: </bold>EAMG was induced in female Lewis rats by immunization with the Torpedo acetylcholine receptor (tAChR) and complete Freund's adjuvant (CFA). NT-1654 was dissolved in phosphate-buffered saline (PBS) and injected daily subcutaneously into tAChR immunized rats during the first 10 days after immunization, and then every other day for the following 20 days.<bold>Results: </bold>We showed that NT-1654 attenuated clinical severity, effectively promoted the clustering of AChRs at NMJs, and alleviated the impairment of NMJ transmission and the reduction of muscle-specific kinase (MuSK) in EAMG rats.<bold>Discussion: </bold>We demonstrated that NT-1654 attenuated clinical severity, effectively promoted the clustering of AChRs at NMJs, and alleviated the impairment of NMJ transmission and the reduction of muscle-specific kinase (MuSK) in EAMG rats. Muscle Nerve 57: 814-820, 2018. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROTEIN metabolism
*CHOLINERGIC receptors
*ACTION potentials
*ANIMAL experimentation
*AUTOANTIBODIES
*BIOLOGICAL models
*COMPARATIVE studies
*DOSE-effect relationship in pharmacology
*ELECTROMYOGRAPHY
*GENES
*IMMUNIZATION
*RESEARCH methodology
*MEDICAL cooperation
*MUSCULAR atrophy
*MYONEURAL junction
*NERVE tissue proteins
*PEPTIDES
*RATS
*RESEARCH
*SOLUTION (Chemistry)
*EVALUATION research
*SKELETAL muscle
*MEMBRANE glycoproteins
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 0148639X
- Volume :
- 57
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Muscle & Nerve
- Publication Type :
- Academic Journal
- Accession number :
- 129209999
- Full Text :
- https://doi.org/10.1002/mus.26025