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RACK1 binds to inositol 1,4,5-trisphosphate receptors and mediates Ca&sup+2; release.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America . 2/24/2004, Vol. 101 Issue 8, p2328-2332. 5p. - Publication Year :
- 2004
-
Abstract
- RACK1 is not a G protein but closely resembles the heterotrimeric Gβ-subunit. RACK1 serves as a scaffold, linking protein kinase C to its substrates. We demonstrate that RACK1 physiologically binds inositol 1,4,5-trisphosphate receptors and regulates Ca2+ release by enhancing inositol 1,4,5-trisphosphate receptor binding affinity for inositol 1,4,5-trisphosphate. Overexpression of RACK1 or depletion of RACK1 by interference RNA markedly augments or diminishes Ca2+ release, respectively, without affecting Ca2+ entry. These findings establish RACK1 as a physiologic mediator of agonist-induced Ca2+ release. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INOSITOL
*CALCIUM antagonists
*PROTEIN kinase C
*RNA
*BINDING sites
*PHOSPHATES
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 101
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 12927130
- Full Text :
- https://doi.org/10.1073/pnas.0308567100