Back to Search
Start Over
Lessons from single-cell transcriptome analysis of oxygen-sensing cells.
- Source :
-
Cell & Tissue Research . May2018, Vol. 372 Issue 2, p403-415. 13p. - Publication Year :
- 2018
-
Abstract
- The advent of single-cell RNA-sequencing (RNA-Seq) technology has enabled transcriptome profiling of individual cells. Comprehensive gene expression analysis at the single-cell level has proven to be effective in characterizing the most fundamental aspects of cellular function and identity. This unbiased approach is revolutionary for small and/or heterogeneous tissues like oxygen-sensing cells in identifying key molecules. Here, we review the major methods of current single-cell RNA-Seq technology. We discuss how this technology has advanced the understanding of oxygen-sensing glomus cells in the carotid body and helped uncover novel oxygen-sensing cells and mechanisms in the mice olfactory system. We conclude by providing our perspective on future single-cell RNA-Seq research directed at oxygen-sensing cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RNA sequencing
*GENE expression
*OXYGEN
*CELL physiology
*CAROTID body
Subjects
Details
- Language :
- English
- ISSN :
- 0302766X
- Volume :
- 372
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cell & Tissue Research
- Publication Type :
- Academic Journal
- Accession number :
- 129279907
- Full Text :
- https://doi.org/10.1007/s00441-017-2682-0