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Effects of a Group-Mediated Exercise and Dietary Intervention in the Treatment of Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: Results From the IDEA-P Trial.
- Source :
-
Annals of Behavioral Medicine . May2018, Vol. 52 Issue 5, p412-428. 17p. - Publication Year :
- 2018
-
Abstract
- <bold>Background: </bold>Although androgen-deprivation therapy (ADT) is the foundation of treatment for prostate cancer, the physiological impacts of ADT result in functional decline and enhanced risk of chronic disease and metabolic syndrome.<bold>Purpose: </bold>The Individualized Diet and Exercise Adherence Pilot Trial (IDEA-P) is a single-blind, randomized, pilot trial comparing the effects of a group-mediated, cognitive-behavioral (GMCB) exercise and dietary intervention (EX+D) with those of a standard-of-care (SC) control during the treatment of prostate cancer patients undergoing ADT.<bold>Methods: </bold>A total of 32 prostate cancer patients (M age = 66.28, SD = 7.79) undergoing ADT were randomly assigned to the 12-week EX+D intervention (n = 16) or control (n = 16). The primary outcome in IDEA-P was change in mobility performance with secondary outcomes including body composition and muscular strength. Blinded assessment of outcomes were obtained at baseline and at 2- and 3-month follow-ups.<bold>Results: </bold>Favorable adherence and retention rates were observed, and no serious intervention-related adverse events were documented. Intent-to-treat ANCOVA controlling for baseline value and ADT duration demonstrated that EX+D resulted in significantly greater improvements in mobility performance (p < .02), muscular strength (p < .01), body fat percentage (p < .05), and fat mass (p < .03) at 3-month follow-up, relative to control.<bold>Conclusion: </bold>Findings from the IDEA-P trial suggest that a GMCB-based EX+D intervention resulted in significant, clinically meaningful improvements in mobility performance, muscular strength, and body composition, relative to controls. Collectively, these results suggest that the EX+D was a safe and well-tolerated intervention for prostate cancer patients on ADT. The utility of implementing this approach in the treatment of prostate cancer patients on ADT should be evaluated in future large-scale efficacy trials.<bold>Clinical Trial information: </bold>NCT02050906. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANDROGEN drugs
*PROSTATE cancer patients
*PROSTATE cancer treatment
*METABOLIC syndrome risk factors
*BODY composition
*MUSCLE strength
*PROSTATE tumors treatment
*ANTIANDROGENS
*COMBINED modality therapy
*COMPARATIVE studies
*DIET therapy
*EXERCISE therapy
*GROUP psychotherapy
*LONGITUDINAL method
*RESEARCH methodology
*MEDICAL cooperation
*HEALTH outcome assessment
*PROSTATE tumors
*RESEARCH
*PILOT projects
*EVALUATION research
*RANDOMIZED controlled trials
*BLIND experiment
Subjects
Details
- Language :
- English
- ISSN :
- 08836612
- Volume :
- 52
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Annals of Behavioral Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 129280490
- Full Text :
- https://doi.org/10.1093/abm/kax002