Effect of Trigonella, Allium Sativum and Their Mixture on Some Physiological Parameters in Hyperthyroidimic Rats.

Background: alterations in the level of hormones including thyroid hormones lead to physiological/clinical abnormalities. Aim of work: this study aimed to illustrate the protective effect of Trigonella, Allium sativum or their mixture against hyperthyroidism induced by L-thyroxin in male albino rats. Materials and methods: thirty albino rats were divided randomly into five groups. Group A: healthy rats, Group B: normal rats were subcutaneously injected with 500 µg/kg body weight L-thyroxin once daily for two weeks to induce hyperthyroidism, Group C: hyperthyroid rats received oral dose of 250 µg/kg body weight/day Trigonella extract. Group D: hyperthyroid rats received oral dose of 250 µg/kg body weight/day Allium sativum extract. Group E: hyperthyroid rats received mixture of Trigonella and Allium sativum extract. At the end of the experiment. Blood samples were collected for biochemical analysis. Results: hyperthyroid rats had significant increase (P<0.05) in serum levels of triodothyronine (T3), thyroxin (T4), TG, VLDL, AST, ALP, BUN and uric acid as well as a significant decrease in TSH, LDL, HDL, LDL/HDL and TC, total protein and percentage of body weight change compared to the normal control group. Oral administration of these extracts ameliorated most of the tested parameters. Conclusion: This study concluded that Allium sativum, Trigonella or their mixture have a protective effect against hyperthyroidism. [ABSTRACT FROM AUTHOR]