Statistical inference on transformation models: a self-induced smoothing approach.

This paper deals with a general class of transformation models that contains many important semiparametric regression models as special cases. It develops a self-induced smoothing for the maximum rank correlation estimator, resulting in simultaneous point and variance estimation. The self-induced smoothing does not require bandwidth selection, yet provides the right amount of smoothness so that the estimator is asymptotically normal with mean zero (unbiased) and variance-covariance matrix consistently estimated by the usual sandwich-type estimator. An iterative algorithm is given for the variance estimation and shown to numerically converge to a consistent limiting variance estimator. The approach is applied to a data set involving survival times of primary biliary cirrhosis patients. Simulation results are reported, showing that the new method performs well under a variety of scenarios. [ABSTRACT FROM AUTHOR]