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Role of BAG3 in cancer progression: A therapeutic opportunity.

Authors :
De Marco, Margot
Basile, Anna
Iorio, Vittoria
Festa, Michelina
Falco, Antonia
Ranieri, Bianca
Pascale, Maria
Sala, Gianluca
Remondelli, Paolo
Capunzo, Mario
Firpo, Matthew A.
Pezzilli, Raffaele
Marzullo, Liberato
Cavallo, Pierpaolo
De Laurenzi, Vincenzo
Turco, Maria Caterina
Rosati, Alessandra
Source :
Seminars in Cell & Developmental Biology. Jun2018, Vol. 78, p85-92. 8p.
Publication Year :
2018

Abstract

BAG3 is a multifunctional protein that can bind to heat shock proteins (Hsp) 70 through its BAG domain and to other partners through its WW domain, proline-rich (PXXP) repeat and IPV (Ile-Pro-Val) motifs. Its intracellular expression can be induced by stressful stimuli, while is constitutive in skeletal muscle, cardiac myocytes and several tumour types. BAG3 can modulate the levels, localisation or activity of its partner proteins, thereby regulating major cell pathways and functions, including apoptosis, autophagy, mechanotransduction, cytoskeleton organisation, motility. A secreted form of BAG3 has been identified in studies on pancreatic ductal adenocarcinoma (PDAC). Secreted BAG3 can bind to a specific receptor, IFITM2, expressed on macrophages, and induce the release of factors that sustain tumour growth and the metastatic process. BAG3 neutralisation therefore appears to constitute a novel potential strategy in the therapy of PDAC and, possibly, other tumours. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10849521
Volume :
78
Database :
Academic Search Index
Journal :
Seminars in Cell & Developmental Biology
Publication Type :
Academic Journal
Accession number :
129403934
Full Text :
https://doi.org/10.1016/j.semcdb.2017.08.049