Transcriptional programming of tissue-resident memory CD8+ T cells.

Tissue-resident memory CD8 + T cells (T RM ) are localized in non-lymphoid tissues throughout the body where they mediate long-lived protective immunity at common sites of pathogen exposure. As the signals controlling T RM differentiation are uncovered, it is becoming apparent that the dynamic activities of numerous transcription factors are intricately involved in T RM formation. Here, we highlight known transcriptional regulators of T RM differentiation and discuss how understanding the transcriptional programming of CD8 + T cell residency in non-lymphoid tissues can be leveraged to prevent or treat disease. [ABSTRACT FROM AUTHOR]