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Biological correlates of self-reported new and continued abstinence in cannabis cessation treatment clinical trials.
- Source :
-
Drug & Alcohol Dependence . Jun2018, Vol. 187, p270-277. 8p. - Publication Year :
- 2018
-
Abstract
- <bold>Background: </bold>The agreement between self-reported cannabis abstinence with urine cannabinoid concentrations in a clinical trials setting is not well characterized. We assessed the agreement between various cannabinoid cutoffs and self-reported abstinence across three clinical trials, one including contingency management for abstinence.<bold>Methods: </bold>Three cannabis cessation clinical trials where participants reported use and provided weekly urine samples for cannabis and creatinine concentration measurements were included. Bootstrapped data were assessed for agreement between self-reported 7+ day abstinence and urine cannabinoid tests using generalized linear mixed effects models for clustered binary outcomes. One study implemented contingency management for cannabis abstinence. Four hundred and seventy-three participants with 3787 valid urine specimens were included. Urine was analyzed for 11-nor-9-carboxy-Δ9-tetrahydrocannabinol and creatinine using immunoassay methods Biological cutoffs of 50, 100, and 200 ng/ml, as well as changes in CN normalized THCCOOH (25%/50% decrease), were assessed for agreement with self-reported abstinence during the three clinical trials.<bold>Results: </bold>Agreement between measured THCCOOH and self-reported abstinence increases with increasing cutoff concentrations, while the agreement with self-reported non-abstinence decreases with increasing cutoff concentrations. Combining THCCOOH cutoffs with recent changes in CN-THCCOOH provides a better agreement in those self-reporting abstinence. Participants in the studies that received CM for abstinence had a lower agreement between self-reported abstinence and returned to use than those in studies that did not have a contingency management component.<bold>Conclusion: </bold>Using combinations of biological measurements and self-reported abstinence, confirmation of study related abstinence may be verifiable earlier and with greater accuracy than relying on a single measurement. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANNABIS (Genus)
*DRUG abstinence
*CLINICAL drug trials
*URINALYSIS
*CANNABINOIDS
*SUBSTANCE abuse treatment
*MEDICAL marijuana
*SUBSTANCE abuse diagnosis
*BEHAVIOR therapy
*CLINICAL trials
*COMPARATIVE studies
*DRUG use testing
*HYDROCARBONS
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*RESEARCH funding
*SELF-evaluation
*SUBSTANCE abuse
*EVALUATION research
*TREATMENT effectiveness
*BLIND experiment
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 03768716
- Volume :
- 187
- Database :
- Academic Search Index
- Journal :
- Drug & Alcohol Dependence
- Publication Type :
- Academic Journal
- Accession number :
- 129607796
- Full Text :
- https://doi.org/10.1016/j.drugalcdep.2018.03.017