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Discovery of anti-viral molecules and their vital functions in Bombyx mori.

Authors :
Lü, Peng
Pan, Ye
Yang, Yanhua
Zhu, Feifei
Li, Chengjun
Guo, Zhongjian
Yao, Qin
Chen, Keping
Source :
Journal of Invertebrate Pathology. May2018, Vol. 154, p12-18. 7p.
Publication Year :
2018

Abstract

The silkworm Bombyx mori ( B. mori ), a lepidopteran model organism, has become an important model for molecular biology researches with its genome completely sequenced. Silkworms confront different types of virus diseases, mainly including those caused by Bombyx mori nucleopolyhedrovirus (BmNPV), Bombyx mori densovirus type 1 (BmDNV-1), Bombyx mori bidesovirus (BmBDV) which was termed as Bombyx mori densovirus type 2 (BmDNV-2) or Bombyx mori parvo-like virus (BmPLV) before in sericulture. B. mori offers excellent models to study the molecular mechanisms of insect innate immune responses to viruses. A variety of molecules and pathways have been identified to be involved in the immune responses in the silkworm to viruses, such as the antimicrobial peptides, prophenoloxidase-activating system, apoptosis, ROS, small RNA and related molecules. Here in this review, we summarize the current research advances in molecules involved in silkworm anti-virus pathways. Moreover, taking BmNPV as an example, we proposed a schematic model of molecules and pathways involved in silkworm immune responses against virus infection. We hope this review can facilitate further study of antiviral mechanisms in silkworm, and provide a reference for virus diseases in other organisms. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00222011
Volume :
154
Database :
Academic Search Index
Journal :
Journal of Invertebrate Pathology
Publication Type :
Academic Journal
Accession number :
129701308
Full Text :
https://doi.org/10.1016/j.jip.2018.02.012