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Clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma after radical resection.
- Source :
-
Saudi Journal of Gastroenterology . May/Jun2018, Vol. 24 Issue 3, p165-170. 6p. - Publication Year :
- 2018
-
Abstract
- Background/Aim: To investigate the clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma (ESCC) after radical resection. Materials and Methods: A total of 108 ESCC specimens were evaluated by reverse transcriptase-polymerase chain reaction (RT-PCR) to detect MUC1 at the mRNA level and were evaluated by immunohistochemistry (IHC) to detect MUC1 at the protein level. Results: MUC1 mRNA was found in 74 cases by RT-PCR and MUC1 protein expression was found by IHC in 70 cases. Both MUC1 mRNA and protein expression correlated with pT (<0.05), pN (P < 0.01), and pTNM (<0.01). The 5-year survival rates of the patients were 39.8%. In univariate analysis, the 5-year survival rate in the ESCC patients was significantly associated with pT (P < 0.01), pN (P < 0.01), pTNM stage (P < 0.01), and MUC1 mRNA and protein expression (P < 0.05). In multivariate analysis, pN and MUC1 expression were the independent relevant factors. Conclusion: MUC1 expression can become a useful marker to predict poor prognostic factors for 5-year survival rate in patients with ESCC after radical resection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13193767
- Volume :
- 24
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Saudi Journal of Gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 129787050
- Full Text :
- https://doi.org/10.4103/sjg.SJG_420_17