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A novel strategy of transition-metal doping to engineer absorption of carbon dots for near-infrared photothermal/photodynamic therapies.
- Source :
-
Carbon . Aug2018, Vol. 134, p519-530. 12p. - Publication Year :
- 2018
-
Abstract
- It is of extreme importance to engineer the structural characteristics of carbon dots (CDs) to satisfy their practical applications in imaging and medical treatments. Here, Cu,N-doped CDs ( Cu,N -CDs) are a new class of near-infrared-(NIR) light-induced therapeutic agents that were prepared by a one-step hydrothermal method using EDTA·2Na and CuCl 2 . Specifically, Cu ΙΙ was located in the inner of Cu,N -CDs via N-Cu-N complexation, endowing NIR absorption for the production of heat and reactive oxygen species. The relationships between the hydrothermal temperature, NIR absorption, and intrinsic biological activity of the Cu,N -CDs were examined. The hydrothermal temperature significantly affected the latter two when the Cu content in the Cu,N -CDs was changed. The Cu,N -CDs at 180 °C were examined for cancer phototherapeutics in vitro and in vivo . The Cu,N -CDs markedly inhibited cancer via synergistic photothermal/photodynamic therapies. In addition, the Cu,N -CDs could also act as one kind of fluorescence cell-imaging agent and IR thermal imaging agent to visualize the in vitro and in vivo treatment process, respectively. Thus, the present study provides a promising new method to prepare CDs with NIR absorption feature for multifunctional cancer theranostic applications. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00086223
- Volume :
- 134
- Database :
- Academic Search Index
- Journal :
- Carbon
- Publication Type :
- Academic Journal
- Accession number :
- 129792074
- Full Text :
- https://doi.org/10.1016/j.carbon.2018.04.001