Back to Search
Start Over
Preparation of micrometric powders of parathyroid hormone (PTH1–34)-loaded chitosan oligosaccharide by supercritical fluid assisted atomization.
- Source :
-
International Journal of Pharmaceutics . Jul2018, Vol. 545 Issue 1/2, p389-394. 6p. - Publication Year :
- 2018
-
Abstract
- Parathyroid hormone (PTH1–34)-loaded dry powders were fabricated from aqueous solution for pulmonary administration using supercritical fluid assisted atomization introduced by a hydrodynamic cavitation mixer (SAA-HCM). Herein, chitosan oligosaccharide (CSO) was selected as a carrier in an effort to enhance transmucosal absorption of the drug. Well-defined, separated and spherical PTH(1–34)/CSO composite microparticles were obtained, and the particles size could be well controlled with narrow distribution. Aerodynamic performance was determined using next generation impactor (NGI), and the mass median aerodynamic diameter (MMAD) ranged strictly 1–5 μm range with fine particle fraction (FPF) up to 63.51%. The structural integrity of coprecipitated PTH(1–34) was validated by HPLC, FT-IR and circular dichroism, and a high loading efficiency up to 92.8% was obtained. TGA analyses revealed its thermal stability was preserved and XRD patterns showed amorphous structure of particles. The SAA-HCM process is proposed as a green technique for preparation of inhalable protein/polymer composite dry powders without use of any organic solvents. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PARATHYROID hormone
*CHITOSAN
*SUPERCRITICAL fluids
*ATOMIZATION
*DRUG absorption
Subjects
Details
- Language :
- English
- ISSN :
- 03785173
- Volume :
- 545
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- International Journal of Pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 129826083
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2018.05.022