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Rhodium-Catalyzed, Remote Terminal Hydroarylation of Activated Olefins through a Long-Range Deconjugative Isomerization.
- Source :
-
Journal of the American Chemical Society . 5/16/2018, Vol. 140 Issue 19, p6062-6066. 5p. - Publication Year :
- 2018
-
Abstract
- The Rh-catalyzed, remote terminal hydroarylation of active olefins at the C7-position of indoles and the ortho-position of indolines and anilines with the appropriate choice of a N-PtBu2 directing group through long-range deconjugative isomerization has been reported. This transformation not only overcomes the conjugate rule of Michael acceptors but also controls the positional selectivity of indoles, representing a significant advancement in both alkene isomerization and the C-H alkylation of indoles. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RHODIUM catalysts
*ALKENES
*ISOMERIZATION
*INDOLE
*ALKYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 140
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 129941499
- Full Text :
- https://doi.org/10.1021/jacs.8b03560