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MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.
- Source :
-
Journal of Clinical Investigation . Jun2018, Vol. 128 Issue 6, p2551-2568. 18p. - Publication Year :
- 2018
-
Abstract
- Immune imbalance of T lymphocyte subsets is a hallmark of psoriasis, but the molecular mechanisms underlying this aspect of psoriasis pathology are poorly understood. Here, we report that microRNA-210 (miR-210), a miR that is highly expressed in both psoriasis patients and mouse models, induces helper T (Th) 17 and Th1 cell differentiation but inhibits Th2 differentiation through repressing STAT6 and LYN expression, contributing to several aspects of the immune imbalance in psoriasis. Both miR-210 ablation in mice and inhibition of miR-210 by intradermal injection of antagomir-210 blocked the immune imbalance and the development of psoriasis-like inflammation in an imiquimod-induced or IL-23-induced psoriasis-like mouse model. We further showed that TGF-β and IL-23 enhance miR-210 expression by inducing HIF-1α, which recruits P300 and promotes histone H3 acetylation in the miR-210 promoter region. Our results reveal a crucial role for miR-210 in the immune imbalance of T lymphocyte subsets in psoriasis and suggest a potential therapeutic avenue. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PSORIASIS
*PSORIASIS & genetics
*INFLAMMATION
*MICRORNA
*GENETIC overexpression
*CELL differentiation
*T helper cells
*IMMUNOLOGY
*ANIMAL experimentation
*BIOLOGICAL models
*COMPARATIVE studies
*GENES
*LYMPHOCYTES
*RESEARCH methodology
*MEDICAL cooperation
*MICE
*RESEARCH
*RNA
*T cells
*EVALUATION research
Subjects
Details
- Language :
- English
- ISSN :
- 00219738
- Volume :
- 128
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 129969228
- Full Text :
- https://doi.org/10.1172/JCI97426