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Studies on Aculeines: Synthetic Strategy to the Fully Protected Protoaculeine B, the N-Terminal Amino Acid of Aculeine B.
- Source :
-
Organic Letters . 6/1/2018, Vol. 20 Issue 11, p3403-3407. 5p. - Publication Year :
- 2018
-
Abstract
- A synthetic strategy for accessing protoaculeine B (1), the N-terminal amino acid of the highly modified peptide toxin aculeine, was developed via the synthesis of the fully protected natural homologue of 1 with a 12-mer poly(propanediamine). The synthesis of mono(propanediamine) analog 2, as well as core amino acid 3, was demonstrated by this strategy. New amino acid 3 induced convulsions in mice; however, compound 2 showed no such activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMINO acid analysis
*PROPANEDIAMINE
*POLYAMINES
*NITRILES
*ORGANONITROGEN compounds
Subjects
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 20
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 130011366
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b01331