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Cyclodextrins as excipients in tablet formulations.
- Source :
-
Drug Discovery Today . Jun2018, Vol. 23 Issue 6, p1274-1284. 11p. - Publication Year :
- 2018
-
Abstract
- This paper aims to provide a critical review of cyclodextrins as excipients in tablet formulations, highlighting: (i) the principal pharmaceutical applications of cyclodextrins; (ii) the most relevant technological aspects in pharmaceutical formulation development; and (iii) the actual regulatory status of cyclodextrins. Moreover, several illustrative examples are presented. Cyclodextrins can be used as complexing excipients in tablet formulations for low-dose drugs. By contrast, for medium-dose drugs and/or when the complexation efficiency is low, the methods to enhance the complexation efficiency play a key part in reducing the cyclodextrin quantity. In addition, these compounds are used as fillers, disintegrants, binders and multifunctional direct compression excipients of the tablets. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CYCLODEXTRINS
*EXCIPIENTS
*DRUG tablets
*DRUG development
*DRUG dosage
Subjects
Details
- Language :
- English
- ISSN :
- 13596446
- Volume :
- 23
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Drug Discovery Today
- Publication Type :
- Academic Journal
- Accession number :
- 130075668
- Full Text :
- https://doi.org/10.1016/j.drudis.2018.04.009