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Cytotoxic garcimultiflorones K–Q, lavandulyl benzophenones from Garcinia multiflora branches.
- Source :
-
Phytochemistry . Aug2018, Vol. 152, p82-90. 9p. - Publication Year :
- 2018
-
Abstract
- Seven undescribed lavandulyl benzophenones garcimultiflorones K – Q, and fourteen known compounds were isolated from the CHCl 3 soluble fraction of 95% EtOH extract of Garcinia multiflora branches. Their structures and absolute configurations were determined by spectroscopic techniques including NMR spectroscopy, MS analysis, and ECD calculations. Seven isolated compounds expect for garcimultiflorone L and garcimultiflorone O exhibited cytotoxic activities in vitro against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7, and SW480). It is worth mentioning that garcimultiflorone Q exhibited most significant cytotoxicities against five cancer cell lines with IC 50 values ranging from 3.07–12.56 μM. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00319422
- Volume :
- 152
- Database :
- Academic Search Index
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 130124223
- Full Text :
- https://doi.org/10.1016/j.phytochem.2018.04.019