绝经前女性特发性骨质疏松症的临床特点分析.

Objective To observe the clinical characteristics of idiopathic osteoporosis among premenopausal women． Methods 28 idiopathic osteoporosis patients，15 secondary osteoporosis patients and 56 normal cases were selected from 1043 premenopausal women according to the inclusion criteria in Shanghai First People’s hospital between September 2005 and December 2016． Subjects were divided into three groups: idiopathic osteoporosis group，secondary osteoporosis group and control group． Ｒetrospective statistical analyses were performed for basic clinical characteristics，bone turnover markers，bone mineral density ( BMD) and fracture data． Ｒesults BMD of the lumbar spine，femoral neck and hip in the idiopathic osteoporosis group were significantly lower than that of the control group ( t = － 3. 794，P ＜ 0. 01; t = － 4. 080，P ＜ 0. 01; t = － 5. 632，P ＜ 0. 01) ． There were no significant differences in the levels of calcium，phosphorus and vitamin D between the idiopathic osteoporosis group and the control group ( t = 0. 120，P ＞ 0. 05; t = 0. 121，P ＞ 0. 05; t = 0. 004，P ＞ 0. 05) ． There was a trend of lower levels of OC and β-CTX in the idiopathic osteoporosis group than that of the control group，but the differences were not statistically significant ( t = 1. 605，P ＞ 0. 05; t = 1. 543，P ＞ 0. 05) ． BMD of the lumbar spine in the secondary osteoporosis group was significantly lower than that in the idiopathic osteoporosis group ( P = 0. 035) ． However，there were no significant differences in BMD of the femoral neck and hip between the secondary osteoporosis group and the idiopathic osteoporosis group ( P = 0. 298，0. 223) ． The levels of OC and β-CTX in the secondary osteoporosis group were higher than that in control group ( P = 0. 020，P ＜ 0. 01 ) ． There was no significant difference in the level of OC between the secondary osteoporosis group and the idiopathic osteoporosis group ( P ＞ 0. 05) ． The level of β-CTX in the secondary osteoporosis group was higher than that in the idiopathic osteoporosis group ( P ＜ 0. 01) ． Conclusion The pathogenesis of idiopathic osteoporosis in premenopausal women may not be related to the levels of Ca，P and 25OHD，and the high turnover of bone metabolism might be the main cause of the disease．11 [ABSTRACT FROM AUTHOR]