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Asymmetric Total Synthesis of (-)-(3R)-Inthomycin C.
- Source :
-
Organic Letters . 6/15/2018, Vol. 20 Issue 12, p3583-3586. 4p. - Publication Year :
- 2018
-
Abstract
- A short (10 step) and efficient (15% overall yield) synthesis of the natural product (-)-(3R)-inthomycin C is reported. The key steps comprise three C-C bond-forming reactions: (i) a vinylogous Mukaiyama aldol, (ii) an olefin cross-metathesis reaction, and (iii) an asymmetric Mukaiyama-Kiyooka aldol. This route is notable for its brevity and has the advantage of lacking stoichiometric tin-promoted cross-coupling reactions present in previous approaches. Initial investigations on the biological activity of (-)-(3R)-inthomycin C and structural analogues on human cancer cell lines are also described for the first time. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 20
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 130289998
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b01370