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Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicenter DPV study on 24 011 patients from Germany, Austria or Luxembourg.
- Source :
-
Pediatric Diabetes . Aug2018, Vol. 19 Issue 5, p937-944. 8p. 1 Diagram, 3 Charts, 1 Graph. - Publication Year :
- 2018
-
Abstract
- Objective: To investigate differences in cardiovascular risk factors and metabolic control in girls with type 1 diabetes with or without use of oral contraceptives (OC) from the multicenter “diabetes prospective follow‐up” (DPV) registry. Methods: Twenty‐four thousand eleven adolescent girls (13 to < 18 years of age) from Germany, Austria or Luxembourg with type 1 diabetes from the DPV registry were included in this cross‐sectional study. Multivariable regression models were applied to compare clinical characteristics (hemoglobin A1c [HbA1C], blood pressure, serum lipids, body mass index) and lifestyle factors (smoking, physical inactivity, alcohol consumption) between girls with or without OC use. Confounders: age, diabetes duration and migration background. Statistical analysis: SAS 9.4. Results: In girls with type 1 diabetes and OC use, clinical characteristics and lifestyle factors were less favorable compared to non‐users. Differences were most pronounced for the prevalence of dyslipidemia (OC‐users: 40.0% vs non‐users: 29.4; P < .0001) and the number of smokers (OC‐users: 25.9% vs non‐users: 12.5%; P < .0001). OC use, sociodemographic characteristics and lifestyle factors explained between 1 and 7% of the population variance in serum lipids and blood pressure. The use of OC explained a small additional proportion in all variables considered (<1%). Conclusions: OC use in adolescent girls with type 1 diabetes was associated with a poorer cardiovascular risk profile. Biological risk factors were partly explained by a clustering of sociodemographic and lifestyle factors with a small additional contribution of OC use. Prescription of OC should therefore be combined with a screening for cardiovascular risk factors and targeted education. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AGE distribution
*BLOOD pressure
*CARDIOVASCULAR diseases risk factors
*REPORTING of diseases
*ALCOHOL drinking
*GLYCOSYLATED hemoglobin
*HYPERLIPIDEMIA
*TYPE 1 diabetes
*LIPIDS
*LONGITUDINAL method
*MEDICAL cooperation
*MULTIVARIATE analysis
*ORAL contraceptives
*REGRESSION analysis
*RESEARCH
*SMOKING
*SOCIOECONOMIC factors
*BODY mass index
*DISEASE prevalence
*CROSS-sectional method
*DISEASE duration
*SEDENTARY lifestyles
*DATA analysis software
*GLYCEMIC control
*ADOLESCENCE
Subjects
Details
- Language :
- English
- ISSN :
- 1399543X
- Volume :
- 19
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Pediatric Diabetes
- Publication Type :
- Academic Journal
- Accession number :
- 130463988
- Full Text :
- https://doi.org/10.1111/pedi.12656