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Reduced expression of dipeptidyl peptidase (DPP) IV in peripheral blood T lymphocytes of oral cancer patients.
- Source :
-
Journal of Oral Pathology & Medicine . Oct1996, Vol. 25 Issue 9, p507-512. 6p. - Publication Year :
- 1996
-
Abstract
- To investigate the mechanism of decrease of serum DPP IV activity in oral cancer patients, we analyzed the expression of DPP IV in peripheral blood T lymphocytes of oral cancer patients and healthy subjects. Consequently, serum DPP IV activity was found to correlate significantly with the number of peripheral blood lymphocytes (PBL), T lymphocytes and CD26 (identified as DPP IV)+ T lymphocytes in healthy subjects, and the number of PBL and CD26+ T lymphocytes in cancer patients. However, the numbers of PBL and T lymphocytes were significantly less in cancer patients than in healthy subjects. Although the number of CD26+ T lymphocytes was somewhat greater in cancer patients than in healthy subjects, serum DPP IV activity was significantly lower in cancer patients. DPP IV activity and amount of CD26 in T lymphocyte plasma membranes were much less in cancer patients than in healthy subjects. These findings suggest that a decrease in the number of T lymphocytes and the small amount of DPP IV in their plasma membrane may contribute to the decrease of serum DPP IV activity in cancer patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*ORAL cancer patients
*SERUM
*CELL receptors
*BLOOD plasma
*CELL membranes
*ANTIGEN analysis
*ANTIGENS
*COMPARATIVE studies
*FLOW cytometry
*GENES
*RESEARCH methodology
*MEDICAL cooperation
*MOUTH tumors
*PROTEOLYTIC enzymes
*RESEARCH
*WESTERN immunoblotting
*EVALUATION research
*LYMPHOCYTE count
Subjects
Details
- Language :
- English
- ISSN :
- 09042512
- Volume :
- 25
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Oral Pathology & Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 13048021
- Full Text :
- https://doi.org/10.1111/j.1600-0714.1996.tb00306.x