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PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF- B Inactivation.
- Source :
-
Journal of Immunology Research . 7/5/2018, p1-14. 14p. 6 Color Photographs, 1 Diagram, 1 Chart, 2 Graphs. - Publication Year :
- 2018
-
Abstract
- PYR-41 and thalidomide have therapeutic effects on inflammation-associated diseases with side effects such as tumorigenesis. Cross-presentation allows dendritic cells (DC) to present endogenous antigen and induce protective immunity against microbe infection and tumors. But, up to now, the effects of PYR-41 and thalidomide on cross-presentation are still uncertain. In this study, we investigated the effect and mechanism of PYR-41 and thalidomide on DC cross-presentation by observing Myddosome formation, endosomal recruitment of p97 and Sec61, NF-κB activation, and cross-priming ability. We demonstrated that the inhibition of endosomal recruitment of p97 and Sec61, together with attenuated NF-κB activation and Myddosome formation, contributes to PYR-41- and thalidomide-impaired cross-presentation and thereby reverses cross-activation of T cells. These observations suggest that NF-κB signaling and p97 and Sec61 molecules are candidates for dealing with the side effects of PYR-41 and thalidomide. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THALIDOMIDE
*INFLAMMATION treatment
*DRUG side effects
*NEOPLASTIC cell transformation
*PHTHALIMIDES
*THERAPEUTICS
*PROTEIN metabolism
*ANIMAL experimentation
*ANTI-infective agents
*CELLULAR immunity
*CELLULAR signal transduction
*CYTOPLASM
*DENDRITIC cells
*HETEROCYCLIC compounds
*IMMUNOSUPPRESSIVE agents
*MICE
*PROTEINS
*DNA-binding proteins
*NUCLEAR proteins
Subjects
Details
- Language :
- English
- ISSN :
- 23148861
- Database :
- Academic Search Index
- Journal :
- Journal of Immunology Research
- Publication Type :
- Academic Journal
- Accession number :
- 130506053
- Full Text :
- https://doi.org/10.1155/2018/5070573