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Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors.
- Source :
-
Neuropsychiatric Disease & Treatment . Jun2018, Vol. 14, p1569-1583. 15p. - Publication Year :
- 2018
-
Abstract
- Background: Antipsychotic drug (APD) prescription/use in children has increased significantly worldwide, despite limited insight into potential long-term effects of treatment on adult brain functioning. While initial long-term studies have uncovered alterations to behaviors following early APD treatment, further investigations into potential changes to receptor density levels of related neurotransmitter (NT) systems are required. Methods: The current investigation utilized an animal model for early APD treatment with aripiprazole, olanzapine, and risperidone in male and female juvenile rats to investigate potential long-term changes to the adult serotonin (5-HT) NT system. Levels of 5-HT1A, 5-HT2A, and 5-HT2C receptors were measured in the prefrontal cortex (PFC), caudate putamen (CPu), nucleus accumbens (NAc), and hippocampus via Western Blot and receptor autoradiography. Results: In the male cohort, long-term changes to 5-HT2A and 5-HT2C receptors were found mostly across hippocampal and cortical brain regions following early aripiprazole and olanzapine treatment, while early risperidone treatment changed 5-HT1A receptor levels in the NAc and PFC. Lesser effects were uncovered in the female cohort with aripiprazole, olanzapine and risperidone to alter 5-HT1A and 5-HT2A receptors in NAc and hippocampal brain regions, respectively. Conclusion: The results of this study suggest that early treatment of various APDs in juvenile rats may cause gender and brain regional specific changes in 5-HT2A and 5-HT2C receptors in the adult brain. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTIPSYCHOTIC agents
*ARIPIPRAZOLE
*OLANZAPINE
*SEROTONIN
*RISPERIDONE
Subjects
Details
- Language :
- English
- ISSN :
- 11766328
- Volume :
- 14
- Database :
- Academic Search Index
- Journal :
- Neuropsychiatric Disease & Treatment
- Publication Type :
- Academic Journal
- Accession number :
- 130543809
- Full Text :
- https://doi.org/10.2147/NDT.S158545