Back to Search
Start Over
Vasodilator effect of 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea is predominantly mediated through activation of voltage-dependent K+ channels.
- Source :
-
Tropical Journal of Pharmaceutical Research . Jun2018, Vol. 17 Issue 6, p1019-1024. 6p. - Publication Year :
- 2018
-
Abstract
- Purpose: To determine the mechanism of vasorelaxant effect of 1-trifluoromethoxyphenyl - 3 -(1- propionylpiperidin-4-yl) urea (TPPU) in cardiovascular diseases, including hypertension. Methods: Isolated rat thoracic aortic tissue preparations were mounted in an organ bath set up integrated with isometric transducer and a Power Lab assembly. TPPU (0.3 - 100 μM) was tested for vasorelaxant effect against low K+ (25 mM) and high K+ (80 mM)-induced contractions and its mechanism was determined in the presence of different antagonists (glibenclamide, 4- aminopyridine and tetraethyl ammonium). Results: In rat aortic preparations, TPPU showed a concentration-dependent (0.3 - 100 μM) and significant (p < 0.001) inhibition of low K+ induced contractions with complete inhibition obtained at 100 μM. TPPU produced significant (p < 0.05) inhibition of high K+ induced contractions with maximum relaxation of 15.36 ± 1.95 % and 15.85 ± 3.35 % at 30 and 100 μM, respectively. Glibenclamide (Gb,10 μM) pretreatment partially inhibited the vasorelaxant effect of TPPU against low K+ in a concentration range of 1 - 30 μM. 4-Aminopyridine (4-AP, 1 mM) and tetraethyl ammonium (TEA, 10 mM), markedly inhibited the vasorelexant effect of TPPU against low K+ induced contractions with maximum relaxation of 20.09 ± 2.40 and 21.67 ± 0.88 %, respectively, at 100 μM. Conclusion: TPPU possesses marked vasorelaxant properties which provides sound pharmacological evidence for its use as a potential drug candidate in the management of hypertension. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15965996
- Volume :
- 17
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Tropical Journal of Pharmaceutical Research
- Publication Type :
- Academic Journal
- Accession number :
- 130570964
- Full Text :
- https://doi.org/10.4314/tjpr.v17i6.6