Evolution of Total Syntheses of β‐Hydroxy‐γ‐Lactones: Cardiobutanolide and Hagen's Gland Lactones.

Abstract: The β‐hydroxy‐γ‐lactones, cardiobutanolide and Hagen's gland lactones have been interesting targets for total synthesis in many laboratories. There are 10 syntheses reported for cardiobutanolide and 19 syntheses for Hagen's gland lactones. These natural products have the β‐hydroxy‐γ‐lactone moiety in common. The evolution of various synthetic strategies to these natural products from chiral pool materials and/or asymmetric catalysis and involving linear sequences, convergent approaches to the de‐novo protecting group free syntheses have been abstracted in this review. [ABSTRACT FROM AUTHOR]