INTRATHYMIC INOCULATION OF LIVER SPECIFIC ANTIGEN ALLEVIATES LIVER TRANSPLANT REJECTION.

Although major histocompatibility complex (MHC) antigens have been extensively studied, rejiction in liver transplantation has not been resolved completely. HLA matching is not strict in liver tranplantation, both grafts and recipients survive a long period after immunotherapy. Given HLA multiple loci matching, the likelihood of graft dysfunction and rejection increases, suggesting that matching for HLA type exerts a dualistic effect on liver transplantation. The specific antigens only expressed in liver cell membrane or liver cytoplasma, encoded by loci not linked to the MHC gene are called liver specific antigen (ISA).