Facile Preparation of Vinyl S‐Trifluoromethyl NH Aryl Sulfoximines.

We report herein the preparation of ortho‐vinylaryl S‐trifluoromethylated sulfoximines through cross‐coupling reactions. Two efficient palladium‐catalyzed procedures (Stille and Suzuki) were developed, with use of ortho‐iodo aryl sulfoximines as substrates, to give various vinyl derivatives in good yields. The difference in reactivity of the fluorinated derivatives, compared to nonfluorinated counterparts, allowed the use of free NH sulfoximines in the coupling processes, where they proved to be inert to cyclization. Finally, further transformations have been explored, such as metathesis coupling reactions, after post‐functionalization of the nitrogen atom by another vinyl group. [ABSTRACT FROM AUTHOR]