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Effect of Vitamin D Supplementation on Some Inflammatory Biomarkers in Type 2 Diabetes Mellitus Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Source :
-
Annals of Nutrition & Metabolism . Jul2018, Vol. 73 Issue 1, p62-73. 12p. 1 Diagram, 4 Charts, 1 Graph. - Publication Year :
- 2018
-
Abstract
- <bold>Background/Aims:</bold> The mechanism, by which vitamin D influences inflammatory biomarkers in type 2 diabetes mellitus (T2DM), is not very well known. Thus, a meta-analysis of randomized controlled trials was conducted to assess the effect of vitamin D supplementation on some inflammatory biomarkers in T2DM subjects. <bold>Methods:</bold> We searched randomized controlled trials from PubMed and the Cochrane Library in October 2017 and conducted a meta-analysis to evaluate the effectiveness of vitamin D supplementation on high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Either a fixed-effects or a random-effects model was used to calculate pooled effects. <bold>Results:</bold> We identified 13 studies that met our inclusion criteria. The results indicated that the vitamin D supplementation significant decreased the hs-CRP level by 0.45 μg/mL, whereas the vitamin D supplementation did not  influence the TNF-α and IL-6. Subgroup analysis showed that vitamin D significantly lowered hs-CRP by 0.34 μg/mL among trials with a daily vitamin D dose ≤4,000 IU and by 0.31 μg/mL among trials with time of vitamin D supplementation > 12 weeks. <bold>Conclusions:</bold> Vitamin D supplementation is beneficial for the reduction of hs-CRP inT2DM subjects but does not have a significant influence on TNF-α and IL-6 in T2DM subjects. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BIOMARKERS
*C-reactive protein
*DIETARY supplements
*INFLAMMATION
*INFORMATION storage & retrieval systems
*MEDICAL databases
*INTERLEUKINS
*MEDLINE
*META-analysis
*TYPE 2 diabetes
*ONLINE information services
*TUMOR necrosis factors
*VITAMIN D
*SYSTEMATIC reviews
*RANDOMIZED controlled trials
Subjects
Details
- Language :
- English
- ISSN :
- 02506807
- Volume :
- 73
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Annals of Nutrition & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 130931487
- Full Text :
- https://doi.org/10.1159/000490358