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Contribution of BHG and PPHG to Overall Hyperglycemia in T2DM Patients Treated with LM25 and LM50: Post Hoc Analysis of a Randomized Crossover Trial.
- Source :
-
Diabetes Therapy . Aug2018, Vol. 9 Issue 4, p1605-1614. 10p. - Publication Year :
- 2018
-
Abstract
- Introduction: To investigate the relative contribution rates of basal hyperglycemia (BHG) and postprandial hyperglycemia (PPHG) to overall hyperglycemia in patients with type 2 diabetes mellitus (T2DM) treated with insulin lispro mix 25 and 50 (LM25 and LM50) as evaluated by continuous glucose monitoring (CGM).Methods: Eighty-one T2DM patients treated with premixed human insulin 70/30 (PHI70/30) were randomly divided into two groups and received a crossover protocol. In the first 16-week stage, one group received LM25 twice daily, the other group received LM50 twice daily. In the second 16-week stage, the two groups exchanged therapeutic regimen. Glycosylated hemoglobin (HbA1c) measurement and CGM were performed at enrollment and at the end of each treatment stage.Results: BHG’s contribution rate increased with increasing HbA1c (from 34.5% to 60.8%). PPHG’s contribution rates in the LM50 regimen were significantly lower than those in LM25 and PHI70/30 regimens at HbA1c levels < 7.5%. Compared with LM50, LM25 shows a significant difference in reducing HbA1c in the subgroup with baseline HbA1c ≥ 8.5% (ΔHbA1c LM25 vs. LM50 − 0.6 ± 0.1% vs. 0.3 ± 0.1%, p < 0.05).Conclusions: For T2DM patients treated with premixed insulin analogues, postprandial hyperglycemia played a major role in the subgroup of patients with HbA1c < 8.5%, while fasting hyperglycemia became the major contributor to overall hyperglycemia in the subgroup of patients with HbA1c ≥ 8.5%.Trial Registration: Chinese Clinical Trial Registry Identifier ChiCTR-TTRCC-12002516.Funding: Lilly Suzhou Pharmaceutical Co., Ltd. (Shanghai Branch, China) and National Key Program of Clinical Science of China (WBYZ2011-873). [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYPERGLYCEMIA treatment
*BASAL ganglia
*DIABETES prevention
*INSULIN regulation
Subjects
Details
- Language :
- English
- ISSN :
- 18696953
- Volume :
- 9
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Diabetes Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 130970678
- Full Text :
- https://doi.org/10.1007/s13300-018-0462-9