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Gö6983 attenuates titanium particle-induced osteolysis and RANKL mediated osteoclastogenesis through the suppression of NFκB/JNK/p38 pathways.
- Source :
-
Biochemical & Biophysical Research Communications . Sep2018, Vol. 503 Issue 1, p62-70. 9p. - Publication Year :
- 2018
-
Abstract
- Osteoclast activation by wear particles has caused major difficulties for surgeons. Wear particles are the main causes of aseptic prosthetic loosening. Gö6983, a protein kinase C inhibitor, inhibits five subtypes of protein kinase C family members. Here, we found that Gö6983 had an obviously inhibitory effect on wear-particles-induced osteolysis in vivo . In vitro , Gö6983 inhibited RANKL-stimulated osteoclast formation and function by inhibiting the RANKL-stimulated nuclear factor-κB/JNK/p38 signaling pathway. We also observed that Go6983 had no effect on the differentiation of osteoblasts and osteoblast-associated genes expression. According to our data, Gö6983 has potential therapeutic effects for aseptic prosthetic loosening caused by osteoclast activation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TITANIUM
*BONE resorption
*OSTEOCLASTOGENESIS
*PROTEIN kinase C
*OSTEOCLASTS
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 503
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 130988277
- Full Text :
- https://doi.org/10.1016/j.bbrc.2018.05.177