Back to Search
Start Over
Management of locally advanced T3–4 glottic laryngeal carcinomas.
- Source :
-
Journal of Laryngology & Otology . Jul2018, Vol. 132 Issue 7, p642-650. 9p. - Publication Year :
- 2018
-
Abstract
- Objectives: To assess five-year local control and ultimate local control rates of patients treated for locally advanced T3–4 glottic carcinoma with surgery only, radiotherapy only, or surgery plus radiotherapy. Cancer-specific survival, overall survival and rates of malignancy development were also assessed. Methods: A retrospective review was conducted on patients from 1967 to 2015, with analysis of local control, ultimate local control, overall survival and cancer-specific survival performed using Kaplan–Meier and Cox regression. Results: Of 169 eligible patients, the majority (59 per cent) were treated with surgery plus radiotherapy, with laryngectomy being the most common surgical procedure. Local control and ultimate local control rates were higher with surgery only (94.1 per cent) and surgery plus radiotherapy (87.9 and 86.8 per cent respectively), compared to radiotherapy only (46.8 and 52.4 per cent) (both p < 0.001). Cancer-specific survival, overall survival and malignancy development did not differ between groups. Conclusion: Surgery, with or without radiotherapy, offers significantly higher five-year local control and ultimate local control for patients with advanced glottic carcinoma, compared to radiotherapy only. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANCER prognosis
*CANCER treatment
*SQUAMOUS cell carcinoma
*COMBINED modality therapy
*GLOTTIS
*LARYNGECTOMY
*TUMOR classification
*TREATMENT effectiveness
*PROPORTIONAL hazards models
*RETROSPECTIVE studies
*PATIENT selection
*KAPLAN-Meier estimator
*PROGNOSIS
*TUMOR treatment
LARYNGEAL tumors
Subjects
Details
- Language :
- English
- ISSN :
- 00222151
- Volume :
- 132
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Journal of Laryngology & Otology
- Publication Type :
- Academic Journal
- Accession number :
- 130988316
- Full Text :
- https://doi.org/10.1017/S0022215118000993