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2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain.
- Source :
-
Progress in Lipid Research . Jul2018, Vol. 71, p1-17. 17p. - Publication Year :
- 2018
-
Abstract
- 2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB 1 receptor. It is involved in a wide array of (patho)physiological functions, such as emotion, cognition, energy balance, pain sensation and neuroinflammation. In this review, we describe the biosynthetic and metabolic pathways of 2-AG and how chemical and genetic perturbation of these pathways has led to insight in the biological role of this signaling lipid. Finally, we discuss the potential therapeutic benefits of modulating 2-AG levels in the brain. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01637827
- Volume :
- 71
- Database :
- Academic Search Index
- Journal :
- Progress in Lipid Research
- Publication Type :
- Academic Journal
- Accession number :
- 131030555
- Full Text :
- https://doi.org/10.1016/j.plipres.2018.05.002