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Higher versus Lower Continuous Renal Replacement Therapy Intensity in Critically ill Patients with Liver Dysfunction.
- Source :
-
Blood Purification . 2018, Vol. 45 Issue 1-3, p36-43. 8p. - Publication Year :
- 2018
-
Abstract
- <bold>Aims:</bold> To study the association between higher versus lower continuous renal replacement therapy (CRRT) intensity and mortality in critically ill patients with combined acute kidney injury and liver dysfunction. <bold>Methods:</bold> Post-hoc analysis of patients with liver dysfunction (Sequential Organ Failure Assessment liver score ≥2 or diagnosis of liver failure/transplant) included in the Randomized Evaluation of Normal versus Augmented Level renal replacement therapy (RENAL) trial. <bold>Results:</bold> Of 444 patients, 210 (47.3%) were randomized to higher intensity (effluent flow 40 mL/kg/h) and 234 (52.7%) to lower intensity (effluent flow 25 mL/kg/h) therapy. Overall, 79 and 86% of prescribed effluent flow was delivered in the higher-intensity and lower-intensity groups, respectively (p < 0.001). In total, 113 (54.1%) and 120 (51.3%) patients died in each group. On multivariable Cox regression analysis, we found no independent association between higher CRRT intensity and mortality (HR 0.93, 95% CI 0.70-1.24; p = 0.642). <bold>Conclusions:</bold> In RENAL patients with liver dysfunction, higher CRRT intensity was not associated with reduced mortality. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02535068
- Volume :
- 45
- Issue :
- 1-3
- Database :
- Academic Search Index
- Journal :
- Blood Purification
- Publication Type :
- Academic Journal
- Accession number :
- 131041228
- Full Text :
- https://doi.org/10.1159/000480224