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High Loading Dose of Atorvastatin for the Prevention of Serum Creatinine and Cystatin C-Based Contrast-Induced Nephropathy Following Percutaneous Coronary Intervention.
- Source :
-
Angiology . Sep2018, Vol. 69 Issue 8, p692-699. 8p. - Publication Year :
- 2018
-
Abstract
- The aim of this study is to assess the efficacy of high-dose atorvastatin on the prevention of contrast-induced nephropathy (CIN) in patients with acute coronary syndrome (ACS) undergoing percutaneous intervention and observe the incidence of cystatin C (CyC)-based CIN. A total of 496 patients with ACS were randomly assigned to either the control group (247 patients receiving conventional dose atorvastatin 10 mg daily from 1 day before to 3 days after contrast administration) or the high-dose atorvastatin group (249 patients receiving atorvastatin 40 mg daily for the same perioperative period). The baseline characteristics of the 2 groups were similar. The primary end point of serum creatinine (SCr)-based CIN occurred in 31 patients in the control group and 16 patients in the high-dose atorvastatin group (12.6% vs 6.4%; P = .02). Cystatin C-based CIN developed in 90 patients in the control group and 46 patients in the high-dose atorvastatin group (36.4% vs 18.5%; P < .001). A multivariable analysis revealed that high-dose atorvastatin was independently associated with a decreased risk of CIN. Our study demonstrated that prophylactic treatment with high-dose atorvastatin reduced the risk of both SCr and CyC-based CIN and suggested that CyC was a more reliable marker for early diagnosis of CIN compared with SCr. [ABSTRACT FROM AUTHOR]
- Subjects :
- *KIDNEY disease diagnosis
*KIDNEY disease prevention
*KIDNEY disease risk factors
*BIOMARKERS
*CREATININE
*KIDNEY diseases
*MULTIVARIATE analysis
*SURGICAL complications
*RANDOMIZED controlled trials
*TREATMENT effectiveness
*DISEASE incidence
*CONTRAST media
*CYSTATINS
*EARLY diagnosis
*ACUTE coronary syndrome
*ATORVASTATIN
*PERIOPERATIVE care
Subjects
Details
- Language :
- English
- ISSN :
- 00033197
- Volume :
- 69
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 131043858
- Full Text :
- https://doi.org/10.1177/0003319717750903