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Chronic oxidative stress and radiation-induced late normal tissue injury: a review.
- Source :
-
International Journal of Radiation Biology . Apr2004, Vol. 80 Issue 4, p251-259. 9p. - Publication Year :
- 2004
-
Abstract
- Purpose : It is proposed that the development and progression of radiation-induced late effects are driven, in part, by chronic oxidative stress. This mini-review presents data to support this hypothesis and provides the foundation for antioxidant-based interventional approaches directed at modulating late normal tissue injury. Conclusions : Although a causal link between chronic oxidative stress and radiation-induced late normal tissue injury remains to be established, a growing body of evidence appears to support the hypothesis that chronic oxidative stress might serve to drive the progression of radiation-induced late effects. The similarity between chronic tissue injury, chronic inflammation and fibrosis observed in a variety of disease states, including radiation late effects, is provocative and offers the opportunity to apply antioxidant-based therapies to mitigate and/or treat late radiation-induced normal tissue injury. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09553002
- Volume :
- 80
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- International Journal of Radiation Biology
- Publication Type :
- Academic Journal
- Accession number :
- 13104936
- Full Text :
- https://doi.org/10.1080/09553000410001692726