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Inhibition of Mast Cell-Dependent Allergy Reaction by Extract of Black Cohosh (Cimicifuga racemosa).
- Source :
-
Immunopharmacology & Immunotoxicology . May2004, Vol. 26 Issue 2, p299-308. 10p. - Publication Year :
- 2004
-
Abstract
- Black cohosh (Cimiciffuga racemosa) has been used as therapeutics for pain and inflammation in Korean folk medicine. The potential effects of black cohosh extract (BCE) on mast cell-dependent allergy reaction, however, have not been well elucidated yet. In the present study, we investigated the effect of BCE on the allergy reaction using mast cell-dependent in vivo and in vitro models. BCE showed no potential of skin sensitization in local lymph node assay (LLNA). The oral administration of BCE significantly inhibited the anti-IgE-induced passive cutaneous anaphylaxis (PCA) reaction. BCE also showed inhibitory potential on the compound 48/80-induced histamine release from rat peritoneal mast cells. In addition, BCE inhibited the IL-4, IL-5 and TNF-α mRNA induction by PMA and A23187 in human leukemia mast cells, HMC-1. These results demonstrated that BCE has an anti-allergic potential and it may be due to the inhibition of histamine release and cytokine gene expression in the mast cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MAST cell disease
*ALLERGIES
*BUGBANE
*LYMPH nodes
*INFLAMMATION
*MESSENGER RNA
Subjects
Details
- Language :
- English
- ISSN :
- 08923973
- Volume :
- 26
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Immunopharmacology & Immunotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 13108640
- Full Text :
- https://doi.org/10.1081/IPH-120037728