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β-glucans as potential immunoadjuvants: A review on the adjuvanticity, structure-activity relationship and receptor recognition properties.
- Source :
-
Vaccine . Aug2018, Vol. 36 Issue 35, p5235-5244. 10p. - Publication Year :
- 2018
-
Abstract
- β-glucans, a group of polysaccharides exist in many organism species such as mushrooms, yeasts, oats, barley, seaweed, but not mammalians, have a variety of biological activities and applications in drugs and other healthcare products. In recent years, β-glucans have been studied as adjuvants in anti-infection vaccines as well as immunomodulators in anti-cancer immunotherapy. β-glucans can regulate immune responses when administered alone and can connect innate and adaptive immunity to improve immunogenicity of vaccines. When β-glucans act as immunostimulants or adjuvants, a set of receptors have been revealed to recognize β-glucans, including dectin-1, complement receptor 3 (CR3), CD5, lactosylceramide, and so on. Therefore, this review is mainly focused on the application of β-glucans as immune adjuvants, the receptors of β-glucans, as well as their structure and activity relationship which will benefit future research of β-glucans. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GLUCANS
*IMMUNOLOGICAL adjuvants
*POLYSACCHARIDES
*MUSHROOMS
*IMMUNOTHERAPY
Subjects
Details
- Language :
- English
- ISSN :
- 0264410X
- Volume :
- 36
- Issue :
- 35
- Database :
- Academic Search Index
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 131111338
- Full Text :
- https://doi.org/10.1016/j.vaccine.2018.07.038