P-77 - Effects of azoles on processes involving hydroxyl-containing carbon-centered organic radicals.

Free radical fragmentation (FRF) reactions taking place in hydroxyl-containing (HC) biologically relevant substances can make a substantial contribution to the consequences resulting from irradiation of biosystems. HC organic compounds under radiolysis of their aqueous solutions undergo fragmentation that cause damage to carbohydrates, HC lipids and proteins. It has been established earlier that the HC lipids being subjected to radiolysis undergo such fragmentation, giving phosphatidic acid (PA). Accumulation of PA in cancer cells promotes their proliferation. The aforesaid is an important incentive to perform the search for the substances capable of producing an effective regulative action on the probability of FRF reactions occurrence. The object pursued in this study was investigation of the effects produced by azoles on formation of the end products during radiolysis of aqueous solutions of glycerol-1-phosphate (G1F), free radical transformations of that models HC lipids fragmentation. We established ability of nitroazoles to inhibit fragmentation of G1F. This fact open up a new possibility to enhance efficacy of radiation therapy by introducing agents effectively blocking the radiation-induced processes leading to formation of products promoting cancer cell proliferation. [ABSTRACT FROM AUTHOR]