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Iodine-catalyzed synthesis of 5-benzoyl-8H-phthalazino[1,2-b]quinazolin-8-one derivatives via a domino reaction involving a benzyl automatic oxidation by oxygen.
- Source :
-
Tetrahedron . Sep2018, Vol. 74 Issue 36, p4746-4753. 8p. - Publication Year :
- 2018
-
Abstract
- A one-pot procedure for the synthesis of 5-benzoyl-8 H -phthalazino[1,2- b ]quinazolin-8-ones is achieved by an iodine-catalyzed reaction of 2-aminobenzohydrazides and 2-alkynylbenzaldehydes in good yields. The salient feature of this strategy is a domino type process including a condensation, addition, hydroamination, and a noteworthy benzyl automatic oxidation by oxygen under metal-catalyst-free conditions. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IODINE
*QUINAZOLINE
*BENZYL compounds
*HYDRAZIDES
*HYDROAMINATION
*OXIDATION
Subjects
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 74
- Issue :
- 36
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 131145733
- Full Text :
- https://doi.org/10.1016/j.tet.2018.07.042