Back to Search
Start Over
Vaccination with RSV M209-223 peptide promotes a protective immune response associated with reduced pulmonary inflammation.
- Source :
-
Antiviral Research . Sep2018, Vol. 157, p102-110. 9p. - Publication Year :
- 2018
-
Abstract
- Respiratory syncytial virus (RSV) is the most common etiologic agent in severe infections of the lower respiratory tract in children with a high mortality rate. However, there are still no licensed vaccines for RSV. In this study, we investigated a putative vaccine based on M 209-223 peptide. Mice vaccinated with M 209-223 peptide expanded M 209-223 -specific effector CD4 + T cells upon infection. Vaccination resulted in increased numbers of regulatory T cells (Treg) and Th1 cells, and decreased numbers of Th2 cells. In addition, vaccination with M 209-223 peptide, protected mice from infection and prevented lung inflammation, leading to increase in IL-10 and IFN-γ production by lung CD4 + T cells. Treg depletion with anti-CTLA4 antibodies abrogated protection induced by peptide vaccination. Our results support vaccination with M 209-223 peptide as an important strategy to generate protection, both systemic and local, by memory RSV-specific CD4 + T cells in mice. Contrarily to inactivated RSV particles, M 209-223 peptide vaccination is capable of not only promoting viral clearance, but also reducing inflammatory processes in lungs upon infection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01663542
- Volume :
- 157
- Database :
- Academic Search Index
- Journal :
- Antiviral Research
- Publication Type :
- Academic Journal
- Accession number :
- 131145840
- Full Text :
- https://doi.org/10.1016/j.antiviral.2018.07.007