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Effect of carbonic anhydrase-related protein VIII expression on lung adenocarcinoma cell growth
- Source :
-
Lung Cancer (01695002) . Jun2004, Vol. 44 Issue 3, p273-280. 8p. - Publication Year :
- 2004
-
Abstract
- Carbonic anhydrase-related protein VIII (CA-RP VIII) is expressed in most non-small cell lung cancer, and especially strongly at the front of tumor progression. Screening analysis of CA-RP VIII expression in a panel of cultured lung cancer cell lines showed that a well differentiated adenocarcinoma cell line, PC-9, appeared to lack CA-RP VIII. Subsequently, CA8 cDNA was transfected with an expression vector into PC-9. Ectopic overexpression of CA-RP VIII reduced the growth of PC-9 cells on uncoated culture dishes, especially when the cultures were started at low cell density, but increased cell growth on laminin-coated dishes. Interestingly, ectopic CA-RP VIII expression markedly reduced caspase-3 activity induced by serum starvation and anti-cancer agents in PC-9 cells. The present findings suggest that CA-RP VIII expression promotes progression of lung cancer by multifarious mechanisms. [Copyright &y& Elsevier]
- Subjects :
- *PROTEINS
*ADENOCARCINOMA
*APOPTOSIS
*LUNG cancer
Subjects
Details
- Language :
- English
- ISSN :
- 01695002
- Volume :
- 44
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Lung Cancer (01695002)
- Publication Type :
- Academic Journal
- Accession number :
- 13114838
- Full Text :
- https://doi.org/10.1016/j.lungcan.2003.12.011