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Bifunctional Brønsted Base Catalyzed Mannich Reaction of β‐Alkoxy α‐Keto Amides: Stereocontrolled Entry to Functionalized Amino Diols.
- Source :
-
Chemistry - A European Journal . 8/9/2018, Vol. 24 Issue 45, p11554-11558. 5p. - Publication Year :
- 2018
-
Abstract
- Abstract: The potential of β‐alkoxy α‐keto amides as pronucleophiles in the enantioselective Mannich type reaction with p‐nosyl imines is presented. The proper combination of β‐alkoxy α‐keto amides and a squaramide‐based Brønsted base catalyst produced highly enantioenriched Mannich adducts, which may be transformed into functionalized amino diols. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BRONSTED acids
*BASE catalysts
*MANNICH reaction
*AMIDES
*STEREOCHEMISTRY
*GLYCOLS
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 24
- Issue :
- 45
- Database :
- Academic Search Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 131206401
- Full Text :
- https://doi.org/10.1002/chem.201802550