Back to Search
Start Over
Acteoside protects against 6-OHDA-induced dopaminergic neuron damage via Nrf2-ARE signaling pathway.
- Source :
-
Food & Chemical Toxicology . Sep2018, Vol. 119, p6-13. 8p. - Publication Year :
- 2018
-
Abstract
- Acteoside has been reported to have antioxidant and neuroprotective effect, which is a promising therapeutic way in prevention and treatment of Parkinson's disease. The present study was aimed to understand the neuroprotective effect of acteoside and to elucidate its underlying mechanism. 6-hydroxydopamine (6-OHDA)-induced neural damage in zebrafish model was used to study the protective effect of acteoside on Parkinson's disease (PD). Locomotion behavioral test showed that acteoside could prevent 6-OHDA-stimulated movement disorders. Anti-tyrosine hydroxylase (TH) whole-mount immunostaining analysis showed that acteoside could prevent 6-OHDA-induced dopaminergic neuron death. In addition, pretreatment with acteoside could upregulate antioxidative enzymes by activating the Nrf2/ARE signaling pathway in zebrafish. Meanwhile, acteoside was found to be distributed in the brain after intraperitoneal injection into the adult zebrafish, indicating that this compound could penetrate the blood-brain-barrier (BBB). This study demonstrated that acteoside could penetrate BBB and have potential therapeutic value for PD by activating the Nrf2/ARE signaling pathway and attenuating the oxidative stress. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTIOXIDANTS
*CHEMICAL inhibitors
*PARKINSON'S disease
*BRAIN diseases
*ZEBRA danio
Subjects
Details
- Language :
- English
- ISSN :
- 02786915
- Volume :
- 119
- Database :
- Academic Search Index
- Journal :
- Food & Chemical Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 131236523
- Full Text :
- https://doi.org/10.1016/j.fct.2018.06.018