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Reprogramming axial ligands facilitates the self-assembly of a platinum(iv) prodrug: overcoming drug resistance and safer in vivo delivery of cisplatin.
- Source :
-
Chemical Communications . 8/25/2018, Vol. 54 Issue 66, p9167-9170. 4p. - Publication Year :
- 2018
-
Abstract
- We herein reprogrammed axial ligands of platinum(iv) prodrugs, conferring the constructed prodrug entities with the ability to self-assemble in aqueous solution. Further cloaking of the PEG chain with Pluronic surfactant makes this nanoassembly (termed Pt(iv)-NP) suitable for systemic injection. Notably, Pt(iv)-NP significantly alleviated the toxicity of the parent cisplatin drug in vivo while preserving the pharmacological activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PRODRUGS
*DRUG resistance
*CISPLATIN
*UNSATURATED fatty acids
*LIGANDS (Chemistry)
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 54
- Issue :
- 66
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 131247503
- Full Text :
- https://doi.org/10.1039/c8cc03763a