Matrix metalloproteinase targeted peptide vesicles for delivering anticancer drugs.

Authors :: Bhunia, Debmalya
Pradhan, Krishnangsu
Ghosh, Subhajit
Das, Gaurav
Mondal, Prasenjit
Ghosh, Surajit
Source :: Chemical Communications. 8/28/2018, Vol. 54 Issue 67, p9309-9312. 4p.
Publication Year :: 2018
Abstract: A matrix metalloproteinase (MMP) targeted tetrapeptide vesicle has been designed and developed, which strongly binds at a MMP9 enzymatic site. Interestingly, it has a propensity to encapsulate and deliver the doxorubicin drug specifically to the cancer cell, induces superior apoptotic death, and inhibits the metastatic cancer cell migration and growth of multicellular 3D spheroids. [ABSTRACT FROM AUTHOR]

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