Back to Search
Start Over
The Chemo‐selective Reaction of 2‐Amino‐N′‐arylbenzohydrazide and Ketonic Acid Catalyzed by Iodine for the Synthesis of Quinazoline Derivatives.
- Source :
-
Journal of Heterocyclic Chemistry . Aug2018, Vol. 55 Issue 8, p1906-1916. 11p. - Publication Year :
- 2018
-
Abstract
- The chemo‐selective reaction of 2‐amino‐N′‐arylbenzohydrazide and ketonic acid catalyzed by iodine was used to synthesize various 2,3‐dihydroquinazolin‐4(1H)‐ones efficiently. The use of levulinic acid furnished a series of 2,3,3a,4‐tetrahydropyrrolo[1,2‐a]quinazoline‐1,5‐diones in high yields, while acetobutyric acid only afforded the quinazoline skeletons without forming the second pyridine ring. Using alcohol as the solvent instead of ionic liquids, a subsequent esterification was performed with the carboxylic group of acetobutyric acid substrate in one‐pot manner. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMINO acids
*KETONIC acids
*HYDRAZIDES
*ORGANIC synthesis
*QUINAZOLINE
Subjects
Details
- Language :
- English
- ISSN :
- 0022152X
- Volume :
- 55
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Heterocyclic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 131260756
- Full Text :
- https://doi.org/10.1002/jhet.3228